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Sep 29, 2020·Glutamatergic synapses onto pyramidal neurons are diverse in shape, size, and NMDAR-dependent long-term plasticity according to their dendritic location, i.e., proximal or distal to the soma. Deciphering the fine organization of NMDAR subtypes along the dendritic arbor of hippocampal neurons is key to understand the functional diversity of these various synapses.

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P75 Involved in the Ubiquitination of α-synuclein in ...

Sep 15, 2018·Ubiquitination of α-syn requires ligase E3, which assists or directly catalyzes the transfer of ubiquitin from the E2 to the protein substrate. In the pathogenesis of PD, ubiquitin-protein ligase including seven in absentia homolog (siAH), Parkin and ubiquitin carboxy terminal hydrolases L1 (UCH-L1) are associated with α-syn aggregation ...

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NEDD4-mediated HSF1 degradation underlies α-synucleinopathy

Jan 15, 2016·α-Syn-induced HSF1 degradation is mediated by the E3 ligase NEDD4 UPS degradation is mediated by ubiquitin E3 ligase conjugating ubiquitin molecules to a lysine residue of substrate protein. Previously, we discovered that E3 ubiquitin-protein ligase NEDD4 expression was upregulated in the brain samples of PD patients ( 16 ).

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Movo Photo FC50C 16-Foot (5m) Heavy-Duty E-TTL Off-Camera Flash Shoe Cord for Canon EOS 600EX-RT, 430EX, 320EX, 270EX, 90EX, MT-24EX, etc (OC-E3 Replacement) + Bonus Neat Strap by Movo $19.95 $ 19 . 95

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P75 Involved in the Ubiquitination of α-synuclein in ...

Sep 15, 2018·Ubiquitination of α-syn requires ligase E3, which assists or directly catalyzes the transfer of ubiquitin from the E2 to the protein substrate. In the pathogenesis of PD, ubiquitin-protein ligase including seven in absentia homolog (siAH), Parkin and ubiquitin carboxy terminal hydrolases L1 (UCH-L1) are associated with α-syn aggregation ...

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Play 3 player games at Y8.com. If 1 or 2 players are not enough, try playing these 3+ player games. Three people on the same keyboard. It sounds challenging, however it is possible to share controls like a keyboard. Enjoy this collection of three games at Y8.

How to Sync Your iPhone to iTunes (with Pictures) - wikiHow

Jan 08, 2020·This article was co-authored by our trained team of editors and researchers who validated it for accuracy and comprehensiveness. wikiHow's Content Management Team carefully monitors the work from our editorial staff to ensure that each article is backed by trusted research and meets our high quality standards. The wikiHow Tech Team also followed the article's instructions and verified that ...

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Maximize your unfair advantage with Razer Synapse 3, the unified hardware configuration tool that takes your Razer device to the next level. Get access to advanced options and granular control as you rebind buttons, assign macros, personalize device lighting and more.

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Soluble endogenous oligomeric α-synuclein species in ...

Whereas OC and Officer antibodies detected fibrillar amyloid species co-segregating with the 35 kDa and 72 kDa αSyn molecules in both AD and TgI2.2 samples suggesting that these αSyn forms are prefibrillar oligomeric αSyn assemblies, the 28 kDa αSyn dimers were instead detected with A11 and F8H7 in AD brain tissue and to a lesser extent in ...

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